четверг, 17 марта 2016 г.

Insilico Medicine and CBRM announce a licensing agreement


In 2013 CBRM, a research organization headquartered in Moscow, Russia, sponsored a multi-center study, where multiple in silico predictions generated by scientists at Insilico Medicine were validated on in vitro on senescent cells and analyzed in multiple imaging and microarray experiments. A range of predictions with minimal or no side effects rescued the senescent phenotype and lead to transcriptomic signatures resembling "young" non-senescent cells. Insilico Medicine will receive the research results prior to publication in order to explore synergistic and cumulative effects of these compounds and perform further validation and compounding with the full rights to file for intellectual property and sub-license the findings.
 
The Center for Biogerontology and Regenerative Medicine is supporting multiple multi-disciplinary studies in aging and longevity, organizing industry forums and seminars for young scientists. It is dedicated to reducing Russia's dependence on natural resource-driven economy by fostering a generation of young leaders in systems biology of aging and longevity and age-related diseases. The study validating the efficacy of molecules with predicted geroprotective properties in vitro was one of the landmark research projects of CBRM.

"We are happy to see a list of several hundred molecules promising to extend life span could be narrowed down using computational approaches and tested in vitro. These results give us more confidence that transcriptional response- and signaling pathway activation scoring- based drug discovery strategies may help us repurpose existing safe natural products, drugs and drug combinations that may extend healthy longevity in humans or rejuvenate specific human tissues", said Alex Zhavoronkov, PhD, CEO of Insilico Medicine, Inc. 

"As a former employee of Insilico Medicine, I am happy to see that predictions we made using a novel computational approach can be validated in vitro and I hope to see this work propagate into clinical or preventative medicine practice within the coming decade. CBRM will continue performing cutting-edge experimental and clinical research to extend healthy longevity. We have one of the best teams of young scientists dedicated to preventing age-related diseases and debilitating aging-related conditions", said Andrew Garazha, president of CBRM.

About the Center for Biogerontology and Regenerative Medicine (CBRM)
 
The Center for Biogerontology and Regenerative Medicine was formed as a limited company in Russia to advance research in longevity research and regenerative medicine by a group of young scientists from the Pirogov Medical University, D. Rogachev Federal Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow Institute of Physics and Technology (MIPT) and Lomonosov Moscow State University specializing in bioinformatics and medicine. CBRM is affiliated with the Skolkovo Foundation and is the resident of Biopharmcluster "Northern" at the Moscow Institute of Physics and Technology (MIPT) and has close collaborations and a research agreement with the laboratory of aging and longevity.
http://biogerontology.ru/en

About Insilico Medicine, Inc
 
Insilico Medicine, Inc. is a bioinformatics company located at the Emerging Technology Centers at the Johns Hopkins University Eastern campus in Baltimore. It utilizes advances in genomics, big data analysis and deep learning for in silico drug discovery and drug repurposing for aging and age-related diseases. The company pursues internal drug discovery programs in cancer, Parkinson's, Alzheimer's, sarcopenia and geroprotector discovery and provides services to pharmaceutical companies. Brief company video: https://www.youtube.com/watch?v=l62jlwgL3v8

 

среда, 16 марта 2016 г.

Pharma.AI

Pharma.AI launches to apply artificial intelligence to drug discovery and development

 Insilico Medicine, one of the leaders in advanced signaling pathway activation analysis and deep learning for aging and cancer research is proud to announce the formation of the Pharmaceutical Artificial Intelligence division focused on applying latest advances in artificial intelligence to streamline drug discovery and drug repurposing processes and significantly cutting time to market.

With the exception of cancer immunology, most of the pharmaceutical companies are facing declining returns on their R&D investments and are not open to external innovation in early stage development. Pharma.AI aims to bridge this gap by providing cutting-edge machine learning services delivered by an experienced team of bioinformatics and deep learning experts working with millions of drugs, annotated gene expression samples and blood biochemistry data sets that can be used to augment customer's data.

"Since its inception Insilico Medicine is taking the umbrella view on aging research developing biomarkers and drug candidates in a broad number of fields. We collaborate with some of the largest pharmaceutical companies, cosmetics companies and academic institutions on a number of disease- or drug-specific projects. However, our focus on aging and "we do everything" approach is confusing for many of our customers and partners and with the launch of Pharma.AI as a division, we will highlight a core part of our business and explore the possibility of spinning it off as a separate company in the future", said Alex Zhavoronkov, PhD, CEO of Insilico Medicine, Inc.

With 11 highly-expert machine learning experts worldwide, Pharma.AI team is developing deep learned transcriptomics-, proteomics-, blood biochemistry-based biomarkers of multiple diseases, predictors of alternative therapeutic uses of multiple drugs and analytical tools for high-throughput screening. Pharmaceutical companies utilizing Broad Institute's Connectivity Map or LINCS projects of pipelines will find powerful analytical drug discovery tools readily available.

"I am happy to join Pharma.AI division as a research scientist focusing on interpreting the results of our AI analytical systems in skin care applications. I am already supporting this team as a geneticist, but with a full-time appointment I have a chance to help transform the pharmaceutical industry forever. I am also happy with Insilico Medicine's mission to empower women in emerging geographies and giving us visibility and skills that will be in high demand over the next two decades when many other jobs will be lost to automation", said Polina Mamoshina, senior research scientist at Insilico Medicine.

About Insilico Medicine, Inc

Insilico Medicine, Inc. is a bioinformatics company located at the Emerging Technology Centers at the Johns Hopkins University Eastern campus in Baltimore. It utilizes advances in genomics, big data analysis and deep learning for in silico drug discovery and drug repurposing for aging and age-related diseases. The company pursues internal drug discovery programs in cancer, Parkinson's, Alzheimer's, sarcopenia and geroprotector discovery and provides services to pharmaceutical companies. Brief company video: https://www.youtube.com/watch?v=l62jlwgL3v8